| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1973-2419] |
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| Ligand | BDBM50274118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | <1000±n/a nM |
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| Citation |  Beigelman, L; Wang, G; Smith, DB Substituted nucleosides, nucleotides and analogs thereof US Patent US10793591 Publication Date 10/6/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [1973-2419] |
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| Name: | Genome polyprotein [1973-2419] |
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| Synonyms: | Non-structural protein 5A (NS5A) | POLG_HCVCO | RNA-directed RNA polymerase (NS5B) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48705.67 |
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| Organism: | Hepatitis C virus genotype 1b (isolate Con1) (HCV) |
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| Description: | Q9WMX2[1973-2419] |
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| Residue: | 447 |
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| Sequence: | SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCG
AQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVE
VTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLN
QYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLK
ATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPA
EILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRT
VVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLE
GEPGDPDLSDGSWSTVSEEASEDVVCC
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| BDBM50274118 |
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| n/a |
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| Name | BDBM50274118 |
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| Synonyms: | CHEMBL4127030 | US10793591, Compound 7a |
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| Type | Small organic molecule |
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| Emp. Form. | C10H16FN2O15P3 |
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| Mol. Mass. | 516.1581 |
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| SMILES | C[C@@]1(O)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r| |
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| Structure | 
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