| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049] |
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| Ligand | BDBM472537 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBDAlphaScreen Binding Assay |
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| IC50 | 5.00±n/a nM |
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| Citation |  Ramharter, J; Kofink, C; Stadtmueller, H; Wunberg, T Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors US Patent US10829487 Publication Date 11/10/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049] |
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| Name: | GTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049] |
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| Synonyms: | SOS1 and KRAS G12D |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Son of sevenless homolog 1 [564-1049] |
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| Synonyms: | SOS1 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)(564-1049) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56970.22 |
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| Organism: | n/a |
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| Description: | aa 564-1049 |
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| Residue: | 486 |
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| Sequence: | EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNF
VRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQ
PVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIA
RDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSE
LVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQ
ELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSIN
PPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRV
ESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPS
NPRPGT
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| Component 2 |
| Name: | GTPase KRas [1-169,G12D] |
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| Synonyms: | GTPase KRas (KRAS)(1-169)(G12D) | GTPase KRas [1-169] | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 19450.24 |
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| Organism: | n/a |
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| Description: | aa 1-169 |
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| Residue: | 169 |
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| Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK
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| BDBM472537 |
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| n/a |
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| Name | BDBM472537 |
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| Synonyms: | US10829487, Example I-17 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28F3N5O2 |
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| Mol. Mass. | 499.528 |
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| SMILES | C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C12CC(C1)(C2)N1CCOCC1)c1cccc(C(F)F)c1F |r| |
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| Structure | 
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