Reaction Details |
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Target | GTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049] |
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Ligand | BDBM472575 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TBDAlphaScreen Binding Assay |
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IC50 | 5.00±n/a nM |
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Citation | Ramharter, J; Kofink, C; Stadtmueller, H; Wunberg, T Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors US Patent US10829487 Publication Date 11/10/2020 |
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More Info.: | Get all data from this article, Assay Method |
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GTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049] |
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Name: | GTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049] |
Synonyms: | SOS1 and KRAS G12D |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Son of sevenless homolog 1 [564-1049] |
Synonyms: | SOS1 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)(564-1049) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 56970.22 |
Organism: | n/a |
Description: | aa 564-1049 |
Residue: | 486 |
Sequence: | EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNF
VRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQ
PVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIA
RDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSE
LVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQ
ELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSIN
PPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRV
ESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPS
NPRPGT
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Component 2 |
Name: | GTPase KRas [1-169,G12D] |
Synonyms: | GTPase KRas (KRAS)(1-169)(G12D) | GTPase KRas [1-169] | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 19450.24 |
Organism: | n/a |
Description: | aa 1-169 |
Residue: | 169 |
Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK
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BDBM472575 |
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n/a |
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Name | BDBM472575 |
Synonyms: | US10829487, Example I-54 |
Type | Small organic molecule |
Emp. Form. | C22H21F5N4O |
Mol. Mass. | 452.4204 |
SMILES | C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1F)C(C)(F)F |r| |
Structure |
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