| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor TYRO3 |
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| Ligand | BDBM396991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TAM Enzymatic Assay |
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| IC50 | 55±n/a nM |
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| Citation |  Li, Y; Wang, X; He, C Pyrrolotriazine compounds as TAM inhibitors US Patent US10844069 Publication Date 11/24/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase receptor TYRO3 |
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| Name: | Tyrosine-protein kinase receptor TYRO3 |
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| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY |
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| Type: | Protein |
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| Mol. Mass.: | 96894.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06418 |
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| Residue: | 890 |
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| Sequence: | MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
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| BDBM396991 |
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| n/a |
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| Name | BDBM396991 |
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| Synonyms: | US10442810, Example 53 | US10844069, Example 53 | US11591338, Example 53 | US9981975, Example 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H30FN7O3 |
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| Mol. Mass. | 567.6134 |
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| SMILES | Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 |
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| Structure | 
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