| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Mer |
|---|
| Ligand | BDBM397052 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TAM Enzymatic Assay |
|---|
| IC50 | 55±n/a nM |
|---|
| Citation |  Li, Y; Wang, X; He, C Pyrrolotriazine compounds as TAM inhibitors US Patent US10844069 Publication Date 11/24/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Mer |
|---|
| Name: | Tyrosine-protein kinase Mer |
|---|
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 110234.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1498723 |
|---|
| Residue: | 999 |
|---|
| Sequence: | MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
|
|
|
|---|
| BDBM397052 |
|---|
| n/a |
|---|
| Name | BDBM397052 |
|---|
| Synonyms: | US10442810, Example 115 | US10844069, Example 115 | US11591338, Example 115 | US9981975, Example 115 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C38H39FN8O4 |
|---|
| Mol. Mass. | 690.7659 |
|---|
| SMILES | CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)C(C)(C)CCc4n(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12 |
|---|
| Structure | 
|
|---|
Search and Browse
