Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 11 [E76K] |
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Ligand | BDBM384152 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Assay |
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IC50 | 75.0±n/a nM |
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Citation | Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA Heterocyclic inhibitors of PTPN11 US Patent US10851110 Publication Date 12/1/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 11 [E76K] |
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Name: | Tyrosine-protein phosphatase non-receptor type 11 [E76K] |
Synonyms: | PTN11_HUMAN | PTP2C | PTPN11 | Protein-tyrosine phosphatase 1D | SHPTP2 | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)(E76K) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 68019.14 |
Organism: | Homo sapiens (Human) |
Description: | Q06124[E76K] |
Residue: | 593 |
Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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BDBM384152 |
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n/a |
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Name | BDBM384152 |
Synonyms: | (S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]-decan-4-amine | US10280171, Example 38 | US10851110, Example 38 | US11466017, Example 38 |
Type | Small organic molecule |
Emp. Form. | C19H20Cl2N6O |
Mol. Mass. | 419.308 |
SMILES | N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |r| |
Structure |
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