| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM35052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pim-1 Kinase Inhibition Assay |
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| IC50 | 48.0±n/a nM |
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| Citation |  Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent US10875864 Publication Date 12/29/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM35052 |
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| n/a |
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| Name | BDBM35052 |
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| Synonyms: | K00152 | US10047093, 8-39 | US10392392, Example 8-39 | US10875864, EX. 8-39 | US9416132, 8-39 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17ClN4O |
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| Mol. Mass. | 328.796 |
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| SMILES | Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12 |
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| Structure | 
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