Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM476815

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

140±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

Cell-surface receptors

Mol. Mass.:

50647.10

Organism:

Homo sapiens (Human)

Description:

P14416

Residue:

443

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

BDBM476815

n/a

Name

BDBM476815

Synonyms:

US10870660, Compound III-274 | US11345716, Compound III-274

Type

Small organic molecule

Emp. Form.

C24H32F2N4O2S2

Mol. Mass.

510.663

SMILES

Cc1ncc(\C=C\C(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OCC(F)F)sc4CC3)CC2)s1 |r,wU:13.13,wD:10.9,(13.78,3.89,;12.24,3.89,;11.33,5.14,;9.87,4.66,;9.87,3.12,;8.53,2.35,;7.2,3.12,;5.87,2.35,;5.87,.81,;4.53,3.12,;3.2,2.35,;1.87,3.12,;.53,2.35,;.53,.81,;-.8,.04,;-2.14,.81,;-3.47,.04,;-4.74,.91,;-6.21,.46,;-6.78,-.98,;-8.28,-1.3,;-8.44,-2.83,;-9.78,-3.6,;-11.11,-2.83,;-12.44,-3.6,;-12.44,-5.14,;-13.78,-2.83,;-7.04,-3.46,;-6.01,-2.31,;-4.48,-2.54,;-3.35,-1.49,;1.87,.04,;3.2,.81,;11.33,2.65,)|

Structure