Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 11 |
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Ligand | BDBM479339 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SHP2 Allosteric Inhibition Assay |
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IC50 | 13.0±n/a nM |
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Citation | Fu, J; Lou, Y; He, Y Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitors US Patent US10894797 Publication Date 1/19/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 11 |
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Name: | Tyrosine-protein phosphatase non-receptor type 11 |
Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
Type: | Protein phosphatase |
Mol. Mass.: | 68443.59 |
Organism: | Homo sapiens (Human) |
Description: | Q06124 |
Residue: | 593 |
Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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BDBM479339 |
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n/a |
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Name | BDBM479339 |
Synonyms: | 4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl)-6-(hydroxymethyl)pyrazin-2- yl)thio)-6a,7,9,10-tetrahydro-6H-pyrido[3,2- b][1,4]thiazino[4,3-d][1,4]oxazine-8,8-dioxide | US10894797, Compound 28 | US11034705, Compound 28 | US11518772, Compound 28 |
Type | Small organic molecule |
Emp. Form. | C24H32N6O5S2 |
Mol. Mass. | 548.678 |
SMILES | C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5CCS(=O)(=O)CC5COc34)nc2CO)[C@@H]1N |r| |
Structure |
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