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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [49-170] | ||
| Ligand | BDBM480609 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | AlphaScreen Assay | ||
| IC50 | 4.00±n/a nM | ||
| Citation |  Le, K; Soth, MJ; Liu, G; Jones, P; Cross, JB; Mcafoos, TJ; Carroll, CL; Lewis, RT Imidazopiperazinone inhibitors of transcription activating proteins US Patent US10899769 Publication Date 1/26/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [49-170] | |||
| Name: | Bromodomain-containing protein 4 [49-170] | ||
| Synonyms: | BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 14593.14 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | aa 49-170 (BRD4-BD1) | ||
| Residue: | 122 | ||
| Sequence: |
| ||
| BDBM480609 | |||
| n/a | |||
| Name | BDBM480609 | ||
| Synonyms: | 1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquinolin-8-yl)-5,7- dimethyl-3-(tetrahydro-2H- pyran-4-yl)-7,8- dihydroimidazo[1,5a] pyrazin-6(5H)-one | US10899769, Example 90a | US10899769, Example 90b | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27FN6O2 | ||
| Mol. Mass. | 474.53 | ||
| SMILES | CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1 |(1.37,5.11,;.9,3.65,;-.61,3.33,;-1.64,4.47,;-1.09,1.86,;-2.57,1.46,;-.05,.72,;1.45,1.04,;2.7,.13,;3.94,1.04,;3.47,2.5,;4.24,3.84,;5.78,3.84,;6.55,5.17,;5.78,6.5,;4.24,6.5,;3.47,5.17,;1.93,2.5,;2.7,-1.41,;4.03,-2.18,;5.36,-1.41,;4.03,-3.72,;2.7,-4.49,;1.36,-3.72,;.03,-4.49,;-1.3,-3.72,;-1.3,-2.18,;.03,-1.41,;1.36,-2.18,;-2.64,-4.49,;-2.64,-6.03,;-4.1,-6.5,;-5.01,-5.26,;-6.55,-5.26,;-4.1,-4.01,)| | ||
| Structure | 
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