| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
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| Ligand | BDBM485770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| Ki | >3000±n/a nM |
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| Citation |  Almansa-Rosales, C; Yenes-Mínguez, S; Virgili-Bernado, M; Alonso-Xalma, M Quinoline and isoquinoline derivatives for treating pain and pain related conditions US Patent US10941138 Publication Date 3/9/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel subunit alpha-2/delta-1 |
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| Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
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| Synonyms: | CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2-1 | Voltage-dependent calcium channel subunit delta-1 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 1 | Voltage-gated calcium channel subunit alpha-2/delta-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 124544.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54289 |
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| Residue: | 1103 |
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| Sequence: | MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLL
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| BDBM485770 |
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| n/a |
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| Name | BDBM485770 |
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| Synonyms: | (S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen-3-yl)propan-1- amine | US10941138, Example 68 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N2OS |
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| Mol. Mass. | 298.403 |
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| SMILES | CNCC[C@H](Oc1cccc2cnccc12)c1ccsc1 |r| |
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| Structure | 
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