| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor [307-554] |
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| Ligand | BDBM300987 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 5.70±n/a nM |
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| Citation |  Barlaam, BC; O''Donovan, DH; Hughes, SJ; Moss, TA; Nissink, JW; Scott, JS; Yang, B Chemical compounds US Patent US10961241 Publication Date 3/30/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor [307-554] |
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| Name: | Estrogen receptor [307-554] |
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| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 28281.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 307-554 |
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| Residue: | 248 |
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| Sequence: | ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFD
MLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTL
IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDA
HRLHAPTS
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| BDBM300987 |
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| n/a |
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| Name | BDBM300987 |
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| Synonyms: | N-(2-fluoro-4- ((6S,8R)-7-((1- fluorocyclo- propyl)methyl)-8- methyl- 6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinolin- 6-yl)-5- methoxyphenyl)- 1-(3- fluoropropyl) azetidin-3- amine | US10131663, Example 53 | US10590130, Example 53 | US10961241, Example 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34F3N5O |
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| Mol. Mass. | 513.5977 |
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| SMILES | COc1cc(NC2CN(CCCF)C2)c(F)cc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| |
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| Structure | 
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