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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 | ||
| Ligand | BDBM489962 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Caliper Enzyme Assay | ||
| IC50 | 9.05±n/a nM | ||
| Citation |  Vazquez, ML; Kaila, N; Tuttle, JB; Verhoest, PR; Reese, MR; Coffman, KJ; Samad, T; Duerr, JM; Sciabola, S; Parikh, MD Pyrrolo[2,3-d]pyrimidine derivatives US Patent US10966980 Publication Date 4/6/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 | |||
| Name: | Tyrosine-protein kinase JAK3 | ||
| Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
| Type: | Protein | ||
| Mol. Mass.: | 125111.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333 | ||
| Residue: | 1124 | ||
| Sequence: |
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| BDBM489962 | |||
| n/a | |||
| Name | BDBM489962 | ||
| Synonyms: | US10966980, Example 216 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H26N4O3S | ||
| Mol. Mass. | 414.521 | ||
| SMILES | COC(C)c1ccc(cc1)S(=O)(=O)C[C@H]1C[C@H](C1)N(C)c1ncnc2[nH]ccc12 |r,wD:16.19,14.14,(5.01,6.06,;6.1,4.97,;5.7,3.48,;6.79,2.39,;4.21,3.08,;3.81,1.59,;2.33,1.19,;1.24,2.28,;1.64,3.77,;3.12,4.17,;-.25,1.88,;.15,3.37,;-.65,.4,;-1.74,2.28,;-2.83,1.19,;-4.37,1.19,;-4.37,-.35,;-2.83,-.35,;-5.46,-1.44,;-6.79,-.67,;-5.46,-2.98,;-6.79,-3.75,;-6.79,-5.29,;-5.46,-6.06,;-4.12,-5.29,;-2.66,-5.76,;-1.75,-4.52,;-2.66,-3.27,;-4.12,-3.75,)| | ||
| Structure | 
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