| Reaction Details |
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 | Report a problem with these data |
| Target | ADP-ribosylhydrolase ARH3 |
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| Ligand | BDBM421584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ARH3 Assay |
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| IC50 | >50000±n/a nM |
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| Citation |  McGonagle, AE; Jordan, AM; Waszkowycz, B; Hutton, CP; Waddell, ID; Hitchin, JR; Smith, KM; Hamilton, NM PARG inhibitory compounds US Patent US10995073 Publication Date 5/4/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| ADP-ribosylhydrolase ARH3 |
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| Name: | ADP-ribosylhydrolase ARH3 |
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| Synonyms: | ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38934.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NX46 |
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| Residue: | 363 |
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| Sequence: | MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEP
DPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGV
VTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQL
THASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEER
PYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNS
LQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVF
QKS
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| BDBM421584 |
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| n/a |
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| Name | BDBM421584 |
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| Synonyms: | 3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-fluoro-N-[1-(fluoromethyl)cyclopropyl]-1-methyl-2-oxo-benzimidazole-5-sulfonamide | US10508086, Example 174 | US10995073, Example 174 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13F4N5O3S2 |
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| Mol. Mass. | 451.419 |
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| SMILES | Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 |
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| Structure | 
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