Reaction Details |
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Target | Tryptophan 5-hydroxylase 1 |
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Ligand | BDBM445676 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzyme Activity Assay |
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IC50 | 68.0±8 nM |
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Citation | Bader, M; Specker, E; Matthes, S; Schütz, A; Mallow, K; Grohmann, M; Nazaré, M Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same US Patent US11028104 Publication Date 6/8/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 1 |
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Name: | Tryptophan 5-hydroxylase 1 |
Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
Type: | PROTEIN |
Mol. Mass.: | 50990.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1361824 |
Residue: | 444 |
Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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BDBM445676 |
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n/a |
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Name | BDBM445676 |
Synonyms: | Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | US11028104, Example 14 |
Type | Small organic molecule |
Emp. Form. | C20H18N6O2S |
Mol. Mass. | 406.461 |
SMILES | CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O |
Structure |
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