| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase B2 |
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| Ligand | BDBM173906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TAFI Activity Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 7.70±n/a nM |
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| Comments | extracted |
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| Citation |  Kallus, C; Broenstrup, M; Evers, A; Globisch, A; Schreuder, H; Wagner, M Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa US Patent US9688645 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Carboxypeptidase B2 |
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| Name: | Carboxypeptidase B2 |
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| Synonyms: | CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB |
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| Type: | Enzyme |
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| Mol. Mass.: | 48432.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96IY4 |
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| Residue: | 423 |
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| Sequence: | MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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| BDBM173906 |
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| n/a |
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| Name | BDBM173906 |
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| Synonyms: | US9688645, 3-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H38N4O6 |
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| Mol. Mass. | 490.5924 |
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| SMILES | CC(C)[C@H]1COC\C=C\COc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2 |r,t:7| |
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| Structure | 
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