| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM508614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | competition binding assay |
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| Ki | 0.700±n/a nM |
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| Citation |  Amjad, A; Gallo, GV; Henderson, TJ; Kuang, R; Lim, Y; Lo, MM; Metzger, E; de Lera Ruiz, M; Stamford, A; Tempest, P; Whitehead, B; Wu, H 2,2-difluorodioxolo A2A receptor antagonists US Patent US11046714 Publication Date 6/29/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM508614 |
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| n/a |
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| Name | BDBM508614 |
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| Synonyms: | 8-(2-{(cyclopropylmethyl)[(4- methyl-1,3-thiazol-2- yl)methyl]amino}ethyl)-2,2- difluoro[1,3]dioxolo[4,5- h][1,2,4]triazolo[1,5- c]quinazolin-5-amine | US11046714, Example 60 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F2N7O2S |
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| Mol. Mass. | 473.499 |
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| SMILES | Cc1csc(CN(CCc2nc3c4ccc5OC(F)(F)Oc5c4nc(N)n3n2)CC2CC2)n1 |
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| Structure | 
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