| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 [2-375] |
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| Ligand | BDBM509347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| Ki | 3.00±n/a nM |
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| Citation |  Patel, S; Hamilton, G; Stivala, C; Chen, H; Daniels, B Bicyclic sulfones and sulfoxides and methods of use thereof US Patent US11072617 Publication Date 7/27/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 [2-375] |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 [2-375] |
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| Synonyms: | RIP | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting serine/threonine-protein kinase (RIPK1)(2-375) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42278.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546[2-375] |
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| Residue: | 374 |
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| Sequence: | QPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALL
EEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILE
IIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDG
TAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCI
KSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDV
KSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAP
SLEHPQEENEPSLQ
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| BDBM509347 |
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| n/a |
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| Name | BDBM509347 |
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| Synonyms: | US11072617, Example 73M25 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11F2N3OS |
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| Mol. Mass. | 283.297 |
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| SMILES | FC[S@](=O)c1nc2[C@@H](F)C[C@@H](c3ccccc3)n2n1 |r| |
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| Structure | 
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