| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Anoctamin-1 |
|---|
| Ligand | BDBM509606 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Automated Whole-Cell Patch Clamp Assay to Detect TMEM16A Activity in Recombinant Cells |
|---|
| EC50 | 800±n/a nM |
|---|
| Citation |  Collingwood, S; Mccarthy, C; Hargrave, JD; Hay, DA; Schofield, TB; Ellam, S; Buxton, C; Habgood, M; Ingram, P; Ma, CY; Napier, S; Shaikh, A; Smith, M; Stimson, C; Walker, E COMPOUNDS US Patent US20200361871 Publication Date 11/19/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Anoctamin-1 |
|---|
| Name: | Anoctamin-1 |
|---|
| Synonyms: | ANO1 | ANO1_HUMAN | DOG1 | Discovered on gastrointestinal stromal tumors protein 1 | ORAOV2 | Oral cancer overexpressed protein 2 | TAOS2 | TMEM16A | Transmembrane protein 16A | Tumor-amplified and overexpressed sequence 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 114103.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_828184 |
|---|
| Residue: | 986 |
|---|
| Sequence: | MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRR
KVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYH
EDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK
MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSF
FDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKL
LYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM
DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWA
ATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHI
PEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY
RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEK
SFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL
CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE
PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRA
KDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNV
SDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNL
VMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPC
NHHNTKACPDSLGSPAPSHAYHGGVL
|
|
|
|---|
| BDBM509606 |
|---|
| n/a |
|---|
| Name | BDBM509606 |
|---|
| Synonyms: | N-tert-Butyl-4-[[2-[2-thienyl]acetyl]amino]pyridine-2-carboxamide | US11364246, Example 5 | US20200361871A1, Example 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H19N3O2S |
|---|
| Mol. Mass. | 317.406 |
|---|
| SMILES | CC(C)(C)NC(=O)c1cc(NC(=O)Cc2cccs2)ccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
