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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | ||
| Ligand | BDBM285595 | ||
| Substrate/Competitor | n/a | ||
| IC50 | 25.1±n/a nM | ||
| Citation |  Chappie, TA; Verhoest, PR; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM Imidazopyridazine compounds US Patent US9598421 Publication Date 3/21/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 79875.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q08493 | ||
| Residue: | 712 | ||
| Sequence: |
| ||
| BDBM285595 | |||
| n/a | |||
| Name | BDBM285595 | ||
| Synonyms: | 3-(4-chloro-2-fluorophenyl)-N-[(1R,2S)-2-fluorocyclopro-pyl]imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 68 | US10669279, Example 68 | US9598421, Example 68 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H11ClF2N4O | ||
| Mol. Mass. | 348.735 | ||
| SMILES | F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1F |r,wU:3.4,1.0,(5.5,-1.78,;4.73,-3.11,;4.73,-4.65,;3.39,-3.88,;1.85,-3.88,;1.08,-2.55,;1.85,-1.21,;-.46,-2.55,;-1.36,-3.79,;-2.83,-3.32,;-4.16,-4.09,;-5.5,-3.32,;-5.5,-1.78,;-4.16,-1.01,;-2.83,-1.78,;-1.36,-1.3,;-.96,.19,;.52,.59,;.92,2.07,;-.17,3.16,;.23,4.65,;-1.66,2.76,;-2.05,1.28,;-3.54,.88,)| | ||
| Structure | 
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