Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | ||
| Ligand | BDBM285597 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Scintillation Proximity Assay (SPA) | ||
| IC50 | 36.4±n/a nM | ||
| Citation |  Chappie, TA; Verhoest, PR; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM Imidazopyridazine compounds US Patent US9598421 Publication Date 3/21/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE2 | PDE46 | PDE4A | PDE4A_HUMAN | Phosphodiesterase 4 (PDE4) | Phosphodiesterase 4A | Phosphodiesterase 4A (PDE4) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 98113.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27815 | ||
| Residue: | 886 | ||
| Sequence: |
| ||
| BDBM285597 | |||
| n/a | |||
| Name | BDBM285597 | ||
| Synonyms: | 3-(4-chloro-2-methylphenyl)-N-[(1R,2S)-2-fluorocyclopro-pyl]imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 70 | US10669279, Example 70 | US9598421, Example 70 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H14ClFN4O | ||
| Mol. Mass. | 344.771 | ||
| SMILES | Cc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r,wU:20.22,22.26,(-3.54,.88,;-2.05,1.28,;-1.66,2.76,;-.17,3.16,;.23,4.65,;.92,2.07,;.52,.59,;-.96,.19,;-1.36,-1.3,;-.46,-2.55,;-1.36,-3.79,;-2.83,-3.32,;-4.16,-4.09,;-5.5,-3.32,;-5.5,-1.78,;-4.16,-1.01,;-2.83,-1.78,;1.08,-2.55,;1.85,-1.21,;1.85,-3.88,;3.39,-3.88,;4.73,-4.65,;4.73,-3.11,;5.5,-1.78,)| | ||
| Structure | 
| ||