Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | ||
Ligand | BDBM285621 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Scintillation Proximity Assay (SPA) | ||
IC50 | 12.6±n/a nM | ||
Citation | Chappie, TA; Verhoest, PR; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM Imidazopyridazine compounds US Patent US9598421 Publication Date 3/21/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE2 | PDE46 | PDE4A | PDE4A_HUMAN | Phosphodiesterase 4 (PDE4) | Phosphodiesterase 4A | Phosphodiesterase 4A (PDE4) | ||
Type: | Enzyme | ||
Mol. Mass.: | 98113.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P27815 | ||
Residue: | 886 | ||
Sequence: |
| ||
BDBM285621 | |||
n/a | |||
Name | BDBM285621 | ||
Synonyms: | US10077269, Example 91 | US10669279, Example 91 | US9598421, Example 91 | azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)imidazo[1,2-b]pyridazin-2-yl]methanone | ||
Type | Small organic molecule | ||
Emp. Form. | C16H11ClF2N4O | ||
Mol. Mass. | 348.735 | ||
SMILES | Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1Cl |(3.49,3.03,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,;-.98,1.83,;-2.46,1.44,;-.58,3.32,;.91,3.72,;1.31,5.21,)| | ||
Structure |