| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-nucleotidase |
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| Ligand | BDBM511217 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of the CD73 Enzyme In Vitro |
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| IC50 | 0.230±n/a nM |
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| Citation |  Chen, L; Billedeau, RJ; Li, J Ectonucleotidase inhibitors and methods of use thereof US Patent US11078228 Publication Date 8/3/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-nucleotidase |
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| Name: | 5'-nucleotidase |
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| Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
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| Type: | Enzyme |
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| Mol. Mass.: | 63371.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21589 |
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| Residue: | 574 |
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| Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
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| BDBM511217 |
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| n/a |
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| Name | BDBM511217 |
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| Synonyms: | 2-(((2R,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin-9-yl)-3-ethynyl-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)-2-(4-(2-oxotetrahydropyrimidin-1 (2H)-yl)benzyl)malonic acid | US11078228, Example 141 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30ClN7O8 |
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| Mol. Mass. | 628.033 |
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| SMILES | CNc1nc(Cl)nc2n(cnc12)[C@@H]1C[C@H](COC(Cc2ccc(cc2)N2CCCNC2=O)(C(O)=O)C(O)=O)[C@](O)(C#C)[C@H]1O |r| |
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| Structure | 
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