Reaction Details |
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Target | Serine hydroxymethyltransferase, mitochondrial [30-504] |
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Ligand | BDBM512964 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SHMT1 and SHMT2 Activity Assays |
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IC50 | 5500±n/a nM |
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Citation | Mainolfi, N SHMT inhibitors and uses thereof US Patent US11091451 Publication Date 8/17/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Serine hydroxymethyltransferase, mitochondrial [30-504] |
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Name: | Serine hydroxymethyltransferase, mitochondrial [30-504] |
Synonyms: | GLYM_HUMAN | SHMT2 | Serine hydroxymethyltransferase, mitochondrial (30-504) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 52566.80 |
Organism: | Homo sapiens (Human) |
Description: | aa 30-504 |
Residue: | 475 |
Sequence: | NAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALG
SCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLA
VYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQL
ALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFK
HADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHN
HAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPK
GLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFID
EGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH
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BDBM512964 |
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n/a |
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Name | BDBM512964 |
Synonyms: | US11091451, Compound I-28 |
Type | Small organic molecule |
Emp. Form. | C16H14Cl2N2O3S |
Mol. Mass. | 385.265 |
SMILES | OC(=O)C1(CCC1)NC(=O)Cc1csc(n1)-c1ccc(Cl)cc1Cl |
Structure |
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