| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine hydroxymethyltransferase, mitochondrial [30-504] |
|---|
| Ligand | BDBM512971 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | SHMT1 and SHMT2 Activity Assays |
|---|
| IC50 | 55000±n/a nM |
|---|
| Citation |  Mainolfi, N SHMT inhibitors and uses thereof US Patent US11091451 Publication Date 8/17/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine hydroxymethyltransferase, mitochondrial [30-504] |
|---|
| Name: | Serine hydroxymethyltransferase, mitochondrial [30-504] |
|---|
| Synonyms: | GLYM_HUMAN | SHMT2 | Serine hydroxymethyltransferase, mitochondrial (30-504) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52566.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 30-504 |
|---|
| Residue: | 475 |
|---|
| Sequence: | NAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALG
SCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLA
VYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQL
ALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFK
HADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHN
HAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPK
GLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFID
EGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH
|
|
|
|---|
| BDBM512971 |
|---|
| n/a |
|---|
| Name | BDBM512971 |
|---|
| Synonyms: | US11091451, Compound I-32 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H19ClN2O3S |
|---|
| Mol. Mass. | 366.862 |
|---|
| SMILES | CC[C@@H](C)[C@H](NC(=O)Cc1csc(n1)-c1cccc(Cl)c1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
