| Reaction Details |
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 | Report a problem with these data |
| Target | Serine hydroxymethyltransferase, cytosolic |
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| Ligand | BDBM512990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SHMT1 and SHMT2 Activity Assays |
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| IC50 | 55000±n/a nM |
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| Citation |  Mainolfi, N SHMT inhibitors and uses thereof US Patent US11091451 Publication Date 8/17/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine hydroxymethyltransferase, cytosolic |
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| Name: | Serine hydroxymethyltransferase, cytosolic |
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| Synonyms: | GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53091.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_745716 |
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| Residue: | 483 |
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| Sequence: | MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
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| BDBM512990 |
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| n/a |
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| Name | BDBM512990 |
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| Synonyms: | US11091451, Compound I-45 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12Cl2N2O3S |
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| Mol. Mass. | 371.238 |
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| SMILES | OC(=O)C1(CC1)NC(=O)Cc1csc(n1)-c1ccc(Cl)cc1Cl |
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| Structure | 
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