| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [861-1152] |
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| Ligand | BDBM173935 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK1 Kinase Assay |
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| IC50 | 15±n/a nM |
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| Citation |  Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [861-1152] |
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| Name: | Tyrosine-protein kinase JAK1 [861-1152] |
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| Synonyms: | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1) |
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| Type: | Protein |
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| Mol. Mass.: | 33439.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human JAK1 variant (861-1152 aa) |
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| Residue: | 292 |
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| Sequence: | PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA
DLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ
LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD
RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMT
VTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
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| BDBM173935 |
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| n/a |
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| Name | BDBM173935 |
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| Synonyms: | US9688661, 1-(5-Chloro-2-methylphenyl)-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carbonitrile (compd 63) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12ClN5 |
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| Mol. Mass. | 333.774 |
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| SMILES | Cc1ccc(Cl)cc1-n1cc(cc1C#N)-c1ncnc2[nH]ccc12 |
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| Structure | 
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