| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [861-1152] |
|---|
| Ligand | BDBM173937 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | JAK1 Kinase Assay |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK1 [861-1152] |
|---|
| Name: | Tyrosine-protein kinase JAK1 [861-1152] |
|---|
| Synonyms: | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 33439.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human JAK1 variant (861-1152 aa) |
|---|
| Residue: | 292 |
|---|
| Sequence: | PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA
DLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ
LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD
RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMT
VTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
|
|
|
|---|
| BDBM173937 |
|---|
| n/a |
|---|
| Name | BDBM173937 |
|---|
| Synonyms: | US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carbonitrile (compd 72) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12ClN5 |
|---|
| Mol. Mass. | 309.753 |
|---|
| SMILES | Cc1ccc(Cl)cc1-c1cn(cc1C#N)-c1cc(N)ncn1 |
|---|
| Structure | 
|
|---|
Search and Browse
