| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [861-1152] |
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| Ligand | BDBM173984 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK1 Kinase Assay |
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| IC50 | 52±n/a nM |
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| Citation |  Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [861-1152] |
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| Name: | Tyrosine-protein kinase JAK1 [861-1152] |
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| Synonyms: | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1) |
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| Type: | Protein |
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| Mol. Mass.: | 33439.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human JAK1 variant (861-1152 aa) |
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| Residue: | 292 |
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| Sequence: | PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA
DLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ
LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD
RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMT
VTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
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| BDBM173984 |
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| n/a |
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| Name | BDBM173984 |
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| Synonyms: | US9688661, 2-(5-Chloro-2-ethylphenyl)-5-[6-(methylamino)pyrimidin-4-yl]-1H-pyrrole-3-carboxamide (compd 198) | US9688661, 2-(5-Chloro-2-methylphenyl)-5-[6-(methylamino)pyrimidin-4-yl]-1H-pyrrole-3-carboxamide (compd 190) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15ClN5O |
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| Mol. Mass. | 340.787 |
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| SMILES | CNc1cc(ncn1)-c1cc(C(N)=O)c(n1)-c1cc(Cl)ccc1C |
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| Structure | 
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