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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [861-1152] | ||
| Ligand | BDBM174029 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | JAK1 Kinase Assay | ||
| IC50 | 19±n/a nM | ||
| Citation |  Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [861-1152] | |||
| Name: | Tyrosine-protein kinase JAK1 [861-1152] | ||
| Synonyms: | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 33439.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human JAK1 variant (861-1152 aa) | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM174029 | |||
| n/a | |||
| Name | BDBM174029 | ||
| Synonyms: | US9688661, 5-(6-Aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-N-methyl-1H-pyrrole-3-carboxamide (compd 301) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H20ClN5O | ||
| Mol. Mass. | 369.848 | ||
| SMILES | CCc1ccc(Cl)cc1-c1c(cc(-c2cc(N)ncn2)n1C)C(=O)NC |(5.69,-9.33,;5.29,-7.84,;6.38,-6.76,;7.87,-7.15,;8.95,-6.07,;8.56,-4.58,;9.64,-3.49,;7.07,-4.18,;5.98,-5.27,;4.49,-4.87,;4.02,-3.41,;2.48,-3.41,;2,-4.87,;.51,-5.27,;-.58,-4.18,;-2.06,-4.58,;-3.15,-3.49,;-2.46,-6.07,;-1.37,-7.15,;.11,-6.76,;3.25,-5.77,;3.25,-7.31,;4.79,-2.07,;4.02,-.74,;6.33,-2.07,;7.1,-.74,)| | ||
| Structure | 
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