Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 | ||
Ligand | BDBM174029 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | JAK2 Kinase Assay | ||
IC50 | 5.00±n/a nM | ||
Citation | Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 | |||
Name: | Tyrosine-protein kinase JAK2 | ||
Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
Type: | Protein | ||
Mol. Mass.: | 130684.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674 | ||
Residue: | 1132 | ||
Sequence: |
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BDBM174029 | |||
n/a | |||
Name | BDBM174029 | ||
Synonyms: | US9688661, 5-(6-Aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-N-methyl-1H-pyrrole-3-carboxamide (compd 301) | ||
Type | Small organic molecule | ||
Emp. Form. | C19H20ClN5O | ||
Mol. Mass. | 369.848 | ||
SMILES | CCc1ccc(Cl)cc1-c1c(cc(-c2cc(N)ncn2)n1C)C(=O)NC |(5.69,-9.33,;5.29,-7.84,;6.38,-6.76,;7.87,-7.15,;8.95,-6.07,;8.56,-4.58,;9.64,-3.49,;7.07,-4.18,;5.98,-5.27,;4.49,-4.87,;4.02,-3.41,;2.48,-3.41,;2,-4.87,;.51,-5.27,;-.58,-4.18,;-2.06,-4.58,;-3.15,-3.49,;-2.46,-6.07,;-1.37,-7.15,;.11,-6.76,;3.25,-5.77,;3.25,-7.31,;4.79,-2.07,;4.02,-.74,;6.33,-2.07,;7.1,-.74,)| | ||
Structure |