| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [833-1187] |
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| Ligand | BDBM174025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TYK2 Kinase Assay |
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| IC50 | 58±n/a nM |
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| Citation |  Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-receptor tyrosine-protein kinase TYK2 [833-1187] |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 [833-1187] |
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| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 40613.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human TYK2 variant (833-1187 aa) |
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| Residue: | 355 |
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| Sequence: | LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVF
HKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILR
TLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMA
YLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC
LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGE
RLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
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| BDBM174025 |
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| n/a |
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| Name | BDBM174025 |
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| Synonyms: | US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1H-pyrrole-2-carboxamide (compd 246) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11ClF3N6O |
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| Mol. Mass. | 407.757 |
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| SMILES | NC(=O)c1cn(cn1-c1cc(ccc1Cl)C(F)(F)F)-c1ncnc2C=NCc12 |c:26| |
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| Structure | 
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