Reaction Details |
| Report a problem with these data |
Target | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
---|
Ligand | BDBM8060 |
---|
Substrate/Competitor | Histone H1 |
---|
Meas. Tech. | CDK Kinase Inhibition Assay |
---|
Temperature | 303.15±n/a K |
---|
Ki | 160±n/a nM |
---|
Comments | extracted |
---|
Citation | Wang, S; Meades, C; Wood, G; Osnowski, A; Anderson, S; Yuill, R; Thomas, M; Mezna, M; Jackson, W; Midgley, C; Griffiths, G; Fleming, I; Green, S; McNae, I; Wu, SY; McInnes, C; Zheleva, D; Walkinshaw, MD; Fischer, PM 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. J Med Chem47:1662-75 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
---|
Name: | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
Synonyms: | CDK2/CycE | CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
Component 2 |
Name: | G1/S-specific cyclin-E1 |
Synonyms: | CCNE | CCNE1 | CCNE1_HUMAN |
Type: | Enzyme Subunit |
Mol. Mass.: | 47073.17 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 410 |
Sequence: | MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
|
|
|
BDBM8060 |
---|
Histone H1 |
---|
Name: | Histone H1 |
Synonyms: | n/a |
Type: | Other Protein Type |
Mol. Mass.: | 358.43 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 3 |
Sequence: | |