| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM302992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Activity Assay |
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| IC50 | 0.200±n/a nM |
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| Citation |  Seganish, WM; McElroy, WT; Brumfield, S; Herr, RJ; Yet, L; Yang, J; Harding, III, JP; Ho, GD; Tulshian, D; Yu, W; Wong, MK; Lavey, B; Kozlowski, JA Inhibitors of IRAK4 activity US Patent US9598440 Publication Date 3/21/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM302992 |
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| n/a |
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| Name | BDBM302992 |
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| Synonyms: | US9598440, 133 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N6O3S |
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| Mol. Mass. | 470.588 |
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| SMILES | Cc1csc(n1)-c1cnc(Nc2cc(C)nc(C)c2)nc1N[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)C(C)(C)O |r| |
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| Structure | 
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