| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Ligand | BDBM515209 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| Ki | 3.50±n/a nM |
|---|
| Citation |  Patel, S; Hamilton, G; Zhao, G; Chen, H; Daniels, B; Stivala, C Bicyclic ketone compounds and methods of use thereof US Patent US11098058 Publication Date 8/24/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 75926.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13546 |
|---|
| Residue: | 671 |
|---|
| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
|
|
|
|---|
| BDBM515209 |
|---|
| n/a |
|---|
| Name | BDBM515209 |
|---|
| Synonyms: | US11098058, Example 76 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18FN3O |
|---|
| Mol. Mass. | 311.3534 |
|---|
| SMILES | F[C@H]1C[C@@H](c2ccccc2)n2nc(nc12)C(=O)C1CC2(CC2)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
