| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/6 |
|---|
| Ligand | BDBM515904 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CDK Kinase Assays |
|---|
| IC50 | 23.0±n/a nM |
|---|
| Citation |  Wang, Y; Wang, J; Ding, L Benzimidazole derivatives, preparation methods and uses thereof US Patent US11053238 Publication Date 7/6/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 4/6 |
|---|
| Name: | Cyclin-dependent kinase 4/6 |
|---|
| Synonyms: | CDK6/Cyclin D3 | Cyclin-dependent kinase 4/6 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
|---|
| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 36937.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q00534 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
|
|
|
|---|
| Component 2 |
| Name: | Cyclin-dependent kinase 4 |
|---|
| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33731.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11802 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
|
|
|
|---|
| BDBM515904 |
|---|
| n/a |
|---|
| Name | BDBM515904 |
|---|
| Synonyms: | 4-(6-fluoro-1- methyl-1,2,3,4- tetrahydrobenzo[4,5] imidazo[1,2-a] pyridin-8-yl)-N-(5-(4- methylpiperazin-1- yl)pyridin-2-yl) pyrimidin-2-amine | US11053238, Example 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29FN8 |
|---|
| Mol. Mass. | 472.5605 |
|---|
| SMILES | CC1CCCc2nc3c(F)cc(cc3n12)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
