Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2

Ligand

BDBM516368

Substrate/Competitor

n/a

Meas. Tech.

TYK2 JH2 Domain Binding Assay

<0.2±n/a nM

Citation

Greenwood, JR; Masse, CE TYK2 inhibitors and uses thereof US Patent US11053241 Publication Date 7/6/2021

More Info.:

Get all data from this article, Assay Method

Non-receptor tyrosine-protein kinase TYK2

Name:

Non-receptor tyrosine-protein kinase TYK2

Synonyms:

Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2

Type:

Protein

Mol. Mass.:

133666.03

Organism:

Homo sapiens (Human)

Description:

P29597

Residue:

1187

Sequence:

MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

BDBM516368

n/a

Name

BDBM516368

Synonyms:

US11053241, Compound I-94

Type

Small organic molecule

Emp. Form.

C24H25FN4O3

Mol. Mass.

436.4787

SMILES

CNC(=O)c1cnc(NC(=O)C2CC2)c2[nH]c(cc12)-c1cccc([C@H]2C[C@@H](C2)OC)c1F |r,wU:24.26,wD:26.31,(-5.09,-5.64,;-5.09,-4.1,;-3.76,-3.33,;-2.42,-4.1,;-3.76,-1.79,;-5.09,-1.02,;-5.09,.52,;-3.76,1.29,;-3.76,2.83,;-5.09,3.6,;-5.09,5.14,;-6.42,2.83,;-7.96,2.83,;-7.19,1.5,;-2.42,.52,;-.96,1,;-.05,-.25,;-.96,-1.49,;-2.42,-1.02,;1.49,-.25,;2.26,-1.58,;3.8,-1.58,;4.57,-.25,;3.8,1.09,;4.57,2.42,;4.17,3.91,;5.65,4.3,;6.05,2.82,;6.42,5.64,;7.96,5.64,;2.26,1.09,;1.49,2.42,)|

Structure