| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
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| Ligand | BDBM516402 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determining human Vmat2 Inhibitory Activity of a Compound |
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| Ki | <10±n/a nM |
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| Citation |  Ashweek, N; Harriott, N [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto US Patent US11053242 Publication Date 7/6/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter |
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| Name: | Synaptic vesicular amine transporter |
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| Synonyms: | Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55709.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_610810 |
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| Residue: | 514 |
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| Sequence: | MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
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| BDBM516402 |
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| n/a |
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| Name | BDBM516402 |
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| Synonyms: | US11053242, Compound 2-25 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H42N2O4 |
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| Mol. Mass. | 458.6334 |
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| SMILES | COc1cc2CCN3C[C@@H](CC(C)C)[C@H](COC(=O)C4CCN(C)CC4)C[C@@H]3c2cc1OC |r| |
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| Structure | 
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