Ki Summary

Reaction Details

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Target

Toll-like receptor 7

Ligand

BDBM427741

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.160±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Mussari, CP; Sherwood, TC; Whiteley, BK; Gilmore, JL; Kumar, SR; Pasunoori, L; Srinivas, PV; Duraisamy, SK; Hegde, S; Anumula, RK 4-azaindole compounds US Patent US11053244 Publication Date 7/6/2021

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM427741

n/a

Name

BDBM427741

Synonyms:

US10544143, Example 174 | US10730877, Example 199 | US11053244, Example 199

Type

Small organic molecule

Emp. Form.

C27H34N6O

Mol. Mass.

458.5985

SMILES

COc1cc(cn2ncnc12)-c1[nH]c2ccc(nc2c1C(C)C)C1CCC(CC1)N1CCCC1 |(9.39,.97,;7.85,.97,;7.08,-.36,;5.54,-.36,;4.77,-1.69,;5.54,-3.03,;7.08,-3.03,;8.11,-4.17,;9.51,-3.55,;9.35,-2.01,;7.85,-1.69,;3.23,-1.69,;2.32,-2.94,;.86,-2.46,;-.48,-3.23,;-1.81,-2.46,;-1.81,-.92,;-.48,-.15,;.86,-.92,;2.32,-.45,;2.72,1.04,;1.63,2.13,;4.21,1.44,;-3.14,-.15,;-4.48,-.92,;-5.81,-.15,;-5.81,1.39,;-4.48,2.16,;-3.14,1.39,;-7.14,2.16,;-7.14,3.7,;-8.61,4.17,;-9.51,2.93,;-8.61,1.68,)|

Structure