Reaction Details | |||
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Report a problem with these data | |||
Target | Toll-like receptor 7 | ||
Ligand | BDBM427909 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TLR7/8/9 Inhibition Reporter Assays | ||
IC50 | 0.190±n/a nM | ||
Citation | Dyckman, AJ; Dodd, DS; Mussari, CP; Sherwood, TC; Whiteley, BK; Gilmore, JL; Kumar, SR; Pasunoori, L; Srinivas, PV; Duraisamy, SK; Hegde, S; Anumula, RK 4-azaindole compounds US Patent US11053244 Publication Date 7/6/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Toll-like receptor 7 | |||
Name: | Toll-like receptor 7 | ||
Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) | ||
Type: | Enzyme | ||
Mol. Mass.: | 120945.35 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NYK1 | ||
Residue: | 1049 | ||
Sequence: |
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BDBM427909 | |||
n/a | |||
Name | BDBM427909 | ||
Synonyms: | US10544143, Example 343 | US10544143, Example 344 | US10730877, Example 344 | US11053244, Example 344 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H33FN6O2 | ||
Mol. Mass. | 504.599 | ||
SMILES | COc1cc(cn2ncnc12)-c1[nH]c2cc(F)c(nc2c1C(C)C)C1CCC(CC1)N1CC2(COC2)C1 |(10.09,.69,;8.55,.69,;7.78,-.64,;6.24,-.64,;5.47,-1.97,;6.24,-3.31,;7.78,-3.31,;8.81,-4.45,;10.22,-3.83,;10.05,-2.29,;8.55,-1.97,;3.93,-1.97,;3.02,-3.22,;1.56,-2.74,;.22,-3.51,;-1.11,-2.74,;-2.44,-3.51,;-1.11,-1.2,;.22,-.43,;1.56,-1.2,;3.02,-.73,;3.42,.76,;2.33,1.85,;4.91,1.16,;-2.44,-.43,;-3.78,-1.2,;-5.11,-.43,;-5.11,1.11,;-3.78,1.88,;-2.44,1.11,;-6.44,1.88,;-6.84,3.36,;-8.33,2.96,;-8.73,4.45,;-10.22,4.05,;-9.82,2.57,;-7.93,1.48,)| | ||
Structure |