Ki Summary

Reaction Details

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Target

Toll-like receptor 7

Ligand

BDBM428604

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.170±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Mussari, CP; Sherwood, TC; Whiteley, BK; Gilmore, JL; Kumar, SR; Pasunoori, L; Srinivas, PV; Duraisamy, SK; Hegde, S; Anumula, RK 4-azaindole compounds US Patent US11053244 Publication Date 7/6/2021

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM428604

n/a

Name

BDBM428604

Synonyms:

US10544143, Example 1040 | US10544143, Example 1052 | US10730877, Example 1052 | US11053244, Example 1052

Type

Small organic molecule

Emp. Form.

C29H38N6

Mol. Mass.

470.6522

SMILES

CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC(C)(C)C1)-c1cn2ncnc2c(C)c1C |(4.74,1.33,;3.25,.93,;2.16,2.02,;2.85,-.56,;3.76,-1.8,;2.85,-3.05,;1.39,-2.57,;.05,-3.34,;-1.28,-2.57,;-1.28,-1.03,;.05,-.26,;1.39,-1.03,;-2.62,-.26,;-2.62,1.28,;-3.95,2.05,;-5.28,1.28,;-5.28,-.26,;-3.95,-1.03,;-6.62,2.05,;-7.02,3.53,;-8.5,3.14,;-10.04,3.14,;-9.27,4.47,;-8.1,1.65,;5.3,-1.8,;6.07,-.47,;7.61,-.47,;8.64,.68,;10.04,.05,;9.88,-1.48,;8.38,-1.8,;7.61,-3.14,;8.38,-4.47,;6.07,-3.14,;5.3,-4.47,)|

Structure