| Reaction Details |
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 | Report a problem with these data |
| Target | Cytoplasmic tyrosine-protein kinase BMX |
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| Ligand | BDBM515340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IMAP (Immobilized Metal Ion Affinity-Based Fluorescence Polarization) Assay |
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| IC50 | 1.90±n/a nM |
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| Citation |  Barf, T; de Zwart, E; Verkaik, S; Hoogenboom, N; Demont, D Imidazopyrazine inhibitors of Bruton's tyrosine kinase US Patent US11110088 Publication Date 9/7/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytoplasmic tyrosine-protein kinase BMX |
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| Name: | Cytoplasmic tyrosine-protein kinase BMX |
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| Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 78030.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51813 |
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| Residue: | 675 |
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| Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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| BDBM515340 |
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| n/a |
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| Name | BDBM515340 |
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| Synonyms: | US11110088, Compound Table 1.14 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20F3N7O2 |
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| Mol. Mass. | 507.4672 |
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| SMILES | CC#CC(=O)N[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12 |r| |
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| Structure | 
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