Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM520621 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Measurement of DHODH Inhibitory Enzyme Activity (In Vitro Assays) |
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IC50 | <100.0±n/a nM |
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Citation | Nellore, K; Hosahalli, S Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors US Patent US11147801 Publication Date 10/19/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM520621 |
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n/a |
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Name | BDBM520621 |
Synonyms: | 1-methyl-5-(2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl)-1H-benzo[d][1,2,3]triazole- 7-carboxylic acid; | US11147801, Compound 19 |
Type | Small organic molecule |
Emp. Form. | C20H11F4N3O2 |
Mol. Mass. | 401.3139 |
SMILES | Cn1nnc2cc(cc(C(O)=O)c12)-c1c(F)c(F)c(-c2ccccc2)c(F)c1F |
Structure |
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