| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V1a receptor |
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| Ligand | BDBM521158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cellular In Vitro Assay for Determining Vasopressin Receptor Activity |
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| IC50 | 1.60±n/a nM |
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| Citation |  Collin-Kroepelin, M; Kolkhof, P; Neubauer, T; Fuerstner, C; Pook, E; Wittwer, MB; Schirmer, H; Tinel, H Substituted triazole derivatives and uses thereof US Patent US11149023 Publication Date 10/19/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V1a receptor |
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| Name: | Vasopressin V1a receptor |
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| Synonyms: | AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 46820.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37288 |
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| Residue: | 418 |
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| Sequence: | MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAV
TFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGP
DWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFV
LSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFIC
YNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAY
IVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCV
QSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
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| BDBM521158 |
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| n/a |
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| Name | BDBM521158 |
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| Synonyms: | N-{3-[3-(4-Chlorophenyl)-1-{[1-(3-chloropyridin-2-yl)-1H-1,2,4-triazol-3-yl]methyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-1,1,1-trifluoropropan-2-yl}-4,4-difluoro-prolinamide (Diastereomeric Mixture) | US11149023, Example 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20Cl2F5N9O2 |
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| Mol. Mass. | 632.373 |
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| SMILES | FC(F)(F)C(Cn1c(nn(Cc2ncn(n2)-c2ncccc2Cl)c1=O)-c1ccc(Cl)cc1)NC(=O)C1CC(F)(F)CN1 |
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| Structure | 
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