Reaction Details |
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Target | Estrogen receptor [298-554] |
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Ligand | BDBM521262 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Antagonist Activity on Wild Type (WT) and Mutants |
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IC50 | 0.500±n/a nM |
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Citation | Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof US Patent US11149031 Publication Date 10/19/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Estrogen receptor [298-554] |
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Name: | Estrogen receptor [298-554] |
Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen Receptor alpha (aa 298-554) | NR3A1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 29227.65 |
Organism: | Homo sapiens (Human) |
Description: | P03372[298-554] |
Residue: | 256 |
Sequence: | KRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCV
EGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRV
LDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYD
LLLEMLDAHRLHAPTS
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BDBM521262 |
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n/a |
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Name | BDBM521262 |
Synonyms: | 6-(6-ethoxy-2- fluoro-3- pyridyl)-5-[4- [[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]amino]phenyl]- 8,9-dihydro- 7H- benzo[7]annulen- 2-ol | US11149031, Example 86 |
Type | Small organic molecule |
Emp. Form. | C31H35F2N3O2 |
Mol. Mass. | 519.6253 |
SMILES | CCOc1ccc(c(F)n1)C1=C(c2ccc(N[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 |r,c:11| |
Structure |
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