| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen receptor [298-554] |
|---|
| Ligand | BDBM521385 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Antagonist Activity on Wild Type (WT) and Mutants |
|---|
| IC50 | 2.00±n/a nM |
|---|
| Citation |  Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof US Patent US11149031 Publication Date 10/19/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estrogen receptor [298-554] |
|---|
| Name: | Estrogen receptor [298-554] |
|---|
| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen Receptor alpha (aa 298-554) | NR3A1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 29227.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03372[298-554] |
|---|
| Residue: | 256 |
|---|
| Sequence: | KRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCV
EGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRV
LDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYD
LLLEMLDAHRLHAPTS
|
|
|
|---|
| BDBM521385 |
|---|
| n/a |
|---|
| Name | BDBM521385 |
|---|
| Synonyms: | 5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]-4- [2-fluoro-4- (trideuteriome- thoxy)phenyl]- 2,3-dihydro-1- benzothiepin-8- ol | US11149031, Example 209 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H31F2NO3S |
|---|
| Mol. Mass. | 523.634 |
|---|
| SMILES | COc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2SCC1 |r,c:10| |
|---|
| Structure | 
|
|---|
Search and Browse
