| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombospondin-1 |
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| Ligand | BDBM521733 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TSP1 inhibitory activity |
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| Kd | 0.120±n/a nM |
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| Citation |  Yamaguchi, T; Mori, Y; Saito, H; Kubota, H; Furukawa, A; Otsuka, E; Ishigai, Y; Ijiri, H; Reid, P Thrombospondin 1-binding peptide US Patent US11149066 Publication Date 10/19/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Thrombospondin-1 |
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| Name: | Thrombospondin-1 |
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| Synonyms: | Glycoprotein G | THBS1 | TSP | TSP1 | TSP1_HUMAN | Thrombospondin-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 129327.50 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119903 |
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| Residue: | 1170 |
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| Sequence: | MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFR
IEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVV
SNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELD
VPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLL
TLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRK
VTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSN
ATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQT
RTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARE
TKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQI
CNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACF
NHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKN
AKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPN
LPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYN
HNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEH
NPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDN
DGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRF
QMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDD
DYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNAL
WHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYD
KTYAGGRLGLFVFSQEMVFFSDLKYECRDP
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| BDBM521733 |
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| n/a |
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| Name | BDBM521733 |
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| Synonyms: | US11149066, Compound 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C73H104N18O15S |
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| Mol. Mass. | 1505.783 |
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| SMILES | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC(=O)CNC(=O)[C@H](CO)NC1=O)C(C)C)C(C)C)C(N)=O |r| |
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| Structure | 
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