| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease HTRA3 [111-436] |
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| Ligand | BDBM521757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Chromogenic Enzyme Activity Assays |
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| Ki | 840±n/a nM |
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| Citation |  Kaiser, M; Köcher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors US Patent US11149067 Publication Date 10/19/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease HTRA3 [111-436] |
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| Name: | Serine protease HTRA3 [111-436] |
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| Synonyms: | HTRA3 | HTRA3_HUMAN | High-temperature requirement factor A3 | PRSP | Pregnancy-related serine protease | Serine protease HTRA3 (aa 111-436) |
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| Type: | Protein |
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| Mol. Mass.: | 35381.10 |
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| Organism: | Human |
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| Description: | P83110[111-436] |
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| Residue: | 326 |
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| Sequence: | LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNV
PLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIAT
IKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSD
MDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIK
DWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVK
VNGRPLVDSSELQEAVLTESPLLLEV
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| BDBM521757 |
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| n/a |
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| Name | BDBM521757 |
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| Synonyms: | US11149067, Compound Ahp17 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H68N8O12 |
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| Mol. Mass. | 961.1106 |
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| SMILES | CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](CC=C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O |r| |
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| Structure | 
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