Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase BTK |
---|
Ligand | BDBM521834 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzymatic Activity Assay |
---|
IC50 | 0.300±n/a nM |
---|
Citation | Goldstein, DM; Owens, TD Heterocycle comprising tyrosine kinase inhibitors US Patent US11155544 Publication Date 10/26/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase BTK |
---|
Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
|
|
|
BDBM521834 |
---|
n/a |
---|
Name | BDBM521834 |
Synonyms: | US11155544, Compound 66 |
Type | Small organic molecule |
Emp. Form. | C31H33N7O2 |
Mol. Mass. | 535.6394 |
SMILES | CN1CCN(C[C@@H]1c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12)C(=O)C(=CC(C)(C)C)C#N |w:33.38| |
Structure |
|