Reaction Details |
| Report a problem with these data |
Target | Thioredoxin reductase 1, cytoplasmic |
---|
Ligand | BDBM522176 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition of Recombinant TrxR1 |
---|
IC50 | 76.5±n/a nM |
---|
Citation | Pelcman, B; Suna, E; Stafford, W; Priede, M Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer US Patent US11161815 Publication Date 11/2/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thioredoxin reductase 1, cytoplasmic |
---|
Name: | Thioredoxin reductase 1, cytoplasmic |
Synonyms: | GRIM-12 | GRIM12 | Gene associated with retinoid-IFN-induced mortality 12 protein | KDRF | KM-102-derived reductase-like factor | TR | TRXR1_HUMAN | TXNRD1 | Thioredoxin reductase 1 | Thioredoxin reductase 1 (TrxR) | Thioredoxin reductase TR1 |
Type: | Protein |
Mol. Mass.: | 70761.78 |
Organism: | Homo sapiens (Human) |
Description: | Q16881 |
Residue: | 648 |
Sequence: | MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCG
|
|
|
BDBM522176 |
---|
n/a |
---|
Name | BDBM522176 |
Synonyms: | US11161815, Example 32 |
Type | Small organic molecule |
Emp. Form. | C13H12N2O4S |
Mol. Mass. | 292.31 |
SMILES | COc1ccc(c(n1)S(=O)Cc1ccccc1)[N+]([O-])=O |
Structure |
|